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CasNo： 319460-85-0
MF： C22H18N4OS
Appearance： Off-white solid
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Axitinib is Off-white solid, while it's Molecular Formula is C22H18N4OS. Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
The CAS number of Axitinib is 319460-85-0.
More information of Axitinib 319460-85-0 are:
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Synonyms |
AG013736;Benzamide,N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-; |
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CAS Number |
319460-85-0 |
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Molecular Formula |
C22H18N4OS |
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Molecular Weight |
386.477 |
|
Density |
1.35 g/cm3 |
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Melting Point |
213-215 °C |
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Boiling Point |
668.9 °C at 760 mmHg |
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Flash Point |
358.3 °C |
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HS CODE |
29333990 |
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PSA |
95.97000 |
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LogP |
5.03000 |
|
Pka |
12.70±0.40(Predicted) |
In January 2012, the US FDA approved axitinib (also referred to as AG-013736) for the treatment of advanced renal cell carcinoma (RCC) for patients who have not responded to prior therapy. Axitinib is a pan VEGF inhibitor and functions by binding to the intracellular tyrosine kinase catalytic domain of VEGF leading to blockade of signaling through this angiogenic pathway. Axitinib is50–400 times more potent for VEGF (enzyme Ki and cellular IC50s for VEGF 1, 2, and 3 are ～0.1 nM) than first-generation inhibitors like sorafenib and sunitinib. Axitinib also inhibits c-Kit and PDGFR(α/β) with enzyme Ki's of ～2 nM and was selective when tested against a broad panel of other protein kinases. Axitinib was discovered by a structure-based drug design approach and binds to the kinase domain of VEGF in a DFG-out conformation. Axitinib blocks VEGF-2 phosphorylation up to 7 h postdose in vivo and inhibits endothelial cell proliferation in xenograft tumors implanted in mice. Synthetic routes to axitinib employing a Migita coupling to form the diaryl sulfide and a Heck reaction to install the 2-styrylpyridine moiety have been reported.
InChI:InChI=1/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
Articles related to Axitinib:
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Article |
Source |
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Axitinib: A Photoswitchable Approved Tyrosine Kinase Inhibitor |
Schmidt, Dorian,Rodat, Theo,Heintze, Linda,Weber, Jantje,Horbert, Rebecca,Girreser, Ulrich,Raeker, Tim,Bu?mann, Lara,Kriegs, Malte,Hartke, Bernd,Peifer, Christian , p. 2415 - 2426 (2018) |
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Photoswitchable azo‐ and diazocine‐functionalized derivatives of the vegfr‐2 inhibitor axitinib |
Heintze, Linda,Schmidt, Dorian,Rodat, Theo,Witt, Lydia,Ewert, Julia,Kriegs, Malte,Herges, Rainer,Peifer, Christian , p. 1 - 23 (2020/11/30) |
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