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CasNo： 170729-80-3
MF： C23H21F7N4O3
Appearance： off-white to light yellow cyrstalline solid
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Aprepitant is off-white to light yellow cyrstalline solid, while it's Molecular Formula is C23H21F7N4O3. anticholinergic
The CAS number of Aprepitant is 170729-80-3.
More information of Aprepitant 170729-80-3 are:
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Synonyms |
3H-1,2,4-Triazol-3-one,5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-,[2R-[2a(R*),3a]]-;Emend;L 754030;MK 0869;MK 869;ONO7436; |
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CAS Number |
170729-80-3 |
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Molecular Formula |
C23H21F7N4O3 |
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Molecular Weight |
534.434 |
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Density |
1.51 g/cm3 |
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Melting Point |
75-76°C(lit.) |
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HS CODE |
2934990002 |
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PSA |
83.24000 |
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LogP |
4.89000 |
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Pka |
8.06±0.20(Predicted) |
Aprepitant is an antiemetic chemical compound that belongs to “substance P” antagonists (SPA) with its effect being blocking the neurokinin 1(Nk1) receptor. It is used for the prevention of acute and delayedchemotherapy-induced nausea and vomiting(CINV) and for prevention ofpostoperative nausea and vomiting. It can also be used for the treatment of cyclic vomiting syndrome and late-stage chemotherapy induced vomiting occurring during cancer treatment. Aprepitant alleviates the case of vomiting in patients through balking the signals released by Nk1 receptors. Nk1 is a G-protein-coupled receptor with its ligand being substance P (SP). The high concentration of SP is required for the vomiting reflex. Aprepitant blocks the process of SP-NK1 signaling in activating the vomiting reflex.
InChI:InChI=1/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
Articles related to Aprepitant:
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Article |
Source |
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Preparation method of NK1 receptor antagonist |
- Paragraph 0029; 0031; 0032; 0034; 0035; 0037; 0038; ..., (2021/11/03) |
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Preparation process of aprepitant |
- Paragraph 0038-0094, (2019/03/29) |
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