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CasNo： 3366-95-8
MF： C7H11N3O3
Appearance： Crystalline solid
|
Pharmaceutical Applications |
A 5-nitroimidazole with properties similar to those of metronidazole. It is rapidly absorbed after oral administration and is distinguished by having the longest plasma half-life (18 h) of clinically used nitroimidazole drugs. It is used in the treatment of intestinal amebiasis, giardiasis, trichomoniasis and bacterial vaginosis. |
InChI:InChI=1/C7H11N3O3/c1-5(11)4-9-6(2)8-3-7(9)10(12)13/h3,5,11H,4H2,1-2H3
The invention provides a process for pre...
The invention provides a synthesis metho...
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2-methyl-5-nitro-1H-imidazole
methyloxirane
secnidazole
| Conditions | Yield |
|---|---|
|
With
1-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(dimethylamino)cyclohexyl]thiourea;
In
ethyl acetate;
at 25 - 30 ℃;
for 6h;
Solvent;
Temperature;
Reagent/catalyst;
|
80.5% |
|
With
aluminum (III) chloride;
In
ethyl acetate;
at 45 - 50 ℃;
for 1.5h;
Temperature;
|
75% |
1-bromo-2-propanol
2-methyl-5-nitro-1H-imidazole
secnidazole
| Conditions | Yield |
|---|---|
|
With
potassium carbonate;
In
acetone;
at 70 ℃;
for 5h;
Reagent/catalyst;
Temperature;
|
89.1% |
1-bromo-2-propanol
2-methyl-5-nitro-1H-imidazole
methyloxirane
1-(2-methyl-imidazol-1-yl)-propan-2-ol
1-[4-(4-fluorobenzenesulfonylmethyl)-2-methyl-5-nitroimidazol-1-yl]propan-2-ol
1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl (E)-3-p-tolylacrylate
1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl (E)-3-(3-fluorophenyl)acrylate
1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl (E)-3-(2-chlorophenyl)acrylate
