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  • Product NameSarolaner
  • CasNo. 1398609-39-6
  • MF
  • MW581.372
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Product Details

CasNo： 1398609-39-6

High quality purity >99% Sarolaner 1398609-39-6 for sale

  • Molecular Formula:C23H18Cl2F4N2O5S
  • Molecular Weight:581.372
  • Boiling Point:722.7±70.0 °C(Predicted) 
  • Density:1.65±0.1 g/cm3(Predicted) 

1398609-39-6 Relevant articles

PROCESS FOR PREPARATION OF OPTICALLY ENRICHED ALDOL COMPOUNDS

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Page/Page column 26, (2020/05/28)

The present invention relates to a proce...

Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

Curtis, Michael P.,Vaillancourt, Valerie,Goodwin, Richard M.,Chubb, Nathan A.L.,Howson, William,McTier, Tom L.,Pullins, Aleah,Zinser, Erich W.,Meeus, Patrick F.M.,Woods, Debra J.,Hedges, Laura,Stuk, Tim,Price, Jeffrey E.,Koch, Jason D.,Menon, Sanjay R.

, p. 1831 - 1835 (2016/12/22)

Over the last decade, the isoxazoline mo...

SPIROCYCLIC ISOXAZOLINE DERIVATIVES FOR TREATMENT OF SEA LICE

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Page/Page column 35, (2014/03/26)

The invention recites a method of treati...

CRYSTALLINE FORMS OF 1-(5'-(5-(3,5-DICHLORO-4-FLUOROPHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDROISOXAZOL-3-YL)-3'H-SPIRO[AZETIDINE-3,1'-ISOBENZOFURAN]-1-YL)-2-(METHYLSULFONYL)ETHANONE

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Page/Page column 49, (2014/03/25)

The present invention relates to novel c...

1398609-39-6 Process route

1-[6-[(Z)-C-[(2S)-2-(3,5-dichloro-4-fluorophenyl)-3,3,3-trifluoro-2-hydroxypropyl]-N-hydroxycarbonimidoyl]spiro[1H-isobenzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone

1-[6-[(Z)-C-[(2S)-2-(3,5-dichloro-4-fluorophenyl)-3,3,3-trifluoro-2-hydroxypropyl]-N-hydroxycarbonimidoyl]spiro[1H-isobenzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone

(S)-1-(5’-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3’H-spiro[azetidine-3,1’-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one
1398609-39-6

(S)-1-(5’-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3’H-spiro[azetidine-3,1’-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one

Conditions
Conditions Yield
1-[6-[(Z)-C-[(2S)-2-(3,5-dichloro-4-fluorophenyl)-3,3,3-trifluoro-2-hydroxypropyl]-N-hydroxycarbonimidoyl]spiro[1H-isobenzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;
With methanesulfonyl chloride; In tetrahydrofuran; at 20 - 25 ℃; for 12h;
65%
2-(methylsulfonyl)acetic acid
2516-97-4

2-(methylsulfonyl)acetic acid

5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran] besylate
1573119-85-3

5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran] besylate

(S)-1-(5’-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3’H-spiro[azetidine-3,1’-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one
1398609-39-6

(S)-1-(5’-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3’H-spiro[azetidine-3,1’-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one

Conditions
Conditions Yield
2-(methylsulfonyl)acetic acid; 5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran] besylate; With triethylamine; In ethyl acetate; at 18 - 22 ℃; for 0.5h;
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 10 - 35 ℃;

1398609-39-6 Upstream products

  • 1398609-86-3
    1398609-86-3

    rac-1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone

  • 1398609-82-9
    1398609-82-9

    (Z)-tert-butyl 5'-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-carboxylate

  • 2516-97-4
    2516-97-4

    2-(methylsulfonyl)acetic acid

  • 1573119-85-3
    1573119-85-3

    5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran] besylate

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