CasNo： 74150-27-9
MF： C19H18N4O2
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Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. It is a drug with both inotropic and vasodilatory properties that is used for the treatment of var-ious cardiac diseases.
![(5RS)-6-[1-(4-methoxybenzyl)-2-(4-methoxyphenyl)-1H-benzimidazole-6-yl]-5-methyl-4,5-dihydro-3(2H)pyridazinone](/upload/2025/8/9267deac-1cb3-48a2-90b1-54c5e4bf2680.png)
(5RS)-6-[1-(4-methoxybenzyl)-2-(4-methoxyphenyl)-1H-benzimidazole-6-yl]-5-methyl-4,5-dihydro-3(2H)pyridazinone
pimobendan
| Conditions | Yield |
|---|---|
|
With
ammonium cerium (IV) nitrate;
In
water; acetone;
at 20 ℃;
for 3h;
Temperature;
|
91% |
![6-(2-bromo-1H-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one](/upload/2025/8/1fb56c28-af47-462f-ad94-230625a66dab.png)
6-(2-bromo-1H-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
pimobendan
| Conditions | Yield |
|---|---|
|
6-(2-bromo-1H-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one;
With
caesium carbonate;
In
1,4-dioxane; N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Inert atmosphere;
2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;
With
bis-triphenylphosphine-palladium(II) chloride;
In
1,4-dioxane; N,N-dimethyl-formamide;
at 80 - 85 ℃;
for 12h;
Inert atmosphere;
|
84.9% |
The CAS number of Pimobendan is 74150-27-9.
More information of Pimobendan 74150-27-9 are:
|
CAS Number |
74150-27-9 |
|
Density |
1.36 g/cm3 |
|
Melting Point |
approximate 243℃ (dec.) |
|
Refractive Index |
1.692 |
|
HS CODE |
2933995300 |
|
PSA |
79.37000 |
|
LogP |
2.86300 |
|
Pka |
10.55±0.10(Predicted) |
Synonyms for Pimobendan 74150-27-9:Acardi;Racemic pimobendan;UD-CG 115;UD-CG 115BS;Vetmedin;3(2H)-Pyridazinone,4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl- (9CI);
The chemical formula of Pimobendan is C19H18N4O2 which containing 19 Carbon atoms,18 Hydrogen atoms,4 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of Pimobendan is 334.378.
Pimobendan, a novel cardiotonic vasodilator, was introduced in Japan for the treatment of acute and mild to moderate chronic heart failure. It is a phosphodiesterase Ⅲ inhibitor and is able to enhance sensitization of myocardial contractile regulatory protein to calcium ions. The combination of these effects contribute to its inotropic activity. In patients with severe congestive heart failure, orally administered pimobendan improves cardiac index, stroke volume index, pulmonary wedge pressure, and systemic and pulmonary vascular resistance. Pimobendan is reported to be well tolerated and largely devoid of the proarrhythmic effects of classical phosphodiesterase Ill inhibitors. Studies also suggested that combination of the inotropic agent pimobendan with an ACE inhibitor such as enalapril may be superior to monotherapy for heart failure patients.
InChI:InChI=1/C19H18N4O2/c1-11-9-16(22-23-19(11)24)13-5-8-15-17(10-13)21-18(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,23,24)/t11-/m1/s1
Relevant articles related to Pimobendan:
|
Article |
Source |
|
Synthesis method of pimobendan |
- , (2020/08/29) |
|
Chemical synthesis method of Pimobendan |
- , (2017/05/23) |
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