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CasNo: 57-83-0
MF: C21H30O2
Appearance: Crystalline powder
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White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.
ChEBI: Progesterone is a C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. It has a role as a contraceptive drug, a progestin, a progesterone receptor agonist, a human metabolite and a mouse metabolite. It is a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid hormone. It derives from a hydride of a pregnane.
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.
The CAS number of Progesterone is 57-83-0.
Synonyms for Progesterone 57-83-0:Luteosan;Luteostab;Luteovis;Luteum;Lutex;Lutidon;Lutociclina;Lutocylin;Lutoform;Lutren;Lutromone;NSC 64377;NSC 9704;Prochieve;Progekan;Progestan;Progestasert;Progestogel;Progestol;Progestone;Prolidon;Prontogest;Syntolutan;Utrogest;Utrogestan;Vitarrine;D4-Pregnene-3,20-dione;Natural Micronised Progesterone;Progesterone(8CI);Agolutin;Corluvite;Corporin;Corpus luteum hormone;Crinone;Cyclogest;Duraprogen;Flavolutan;Fologenon;Gestiron;Gestormone;Gestron;Glanducorpin;Gynlutin;Gynolutone;Hormoflaveine;Lugesterone;Luteal Hormone;Luteinique;Luteodyn;Luteogan;Luteopur;Pregn-4-ene-3,20-dione;
Steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.Progesterone is a contaminant of emerging concern (CECs).
InChI:InChI=1/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
Relevant articles related to Progesterone:
Article |
Source |
Regulation of steroidogenesis in the ovine corpus luteum |
Silavin,Moss,Niswender , p. 229 - 241 (1980) |
IDENTIFICATION OF A UNIQUE SERTOLI CELL STEROID AS 3α-HYDROXY-4-PREGNEN-20-ONE (3α-DIHYDROPROGESTERONE: 3α-DHP) |
Wiebe, J. P. , p. 259 - 278 (1982) |
Soft drugs: Thiazolidine-type derivatives of progesterone and testosterone |
Bodor,Sloan , p. 514 - 520 (1982) |
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