CasNo： 113507-06-5
MF： C37H53NO8
Appearance： Appearance White or pale yellow, amorphous powder
Moxidectin 113507-06-5 with purity >99% Low price in stock We supply high quality Moxidectin (CAS 113507-06-5), in stock, factory directly supply to clients, lower prices, more competitiveness.
Moxidectin is Appearance White or pale yellow, amorphous powder, while it's Molecular Formula is C37H53NO8. Moxidectin is a semi-synthetic milbemycin derived from nemadectin by selective oxidation followed by methyloximation. Moxidectin was patented in 1991 as an anthelmintic for internal parasite control. The presence of the methyloxime affords moxidectin a greater hydrophobicity and longer biological half-life compared to nemadectin. Moxidectin binds selectively to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
The CAS number of Moxidectin is 113507-06-5.
More information of Moxidectin 113507-06-5 are:
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Synonyms |
MilbemycinB, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-,[6R,23E,25S(E)]-;Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)- (9CI);23-Methoxime-LL-F 28249a;CL 301423;ProHeart 6;Quest;Quest (parasiticide);Vetdectin Oral Drench;Milbemycin B,5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-buten-1-yl)-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)-; |
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CAS Number |
113507-06-5 |
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Molecular Formula |
C37H53NO8 |
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Molecular Weight |
639.83 |
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Density |
1.23 g/cm3 |
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Melting Point |
132 °C |
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Boiling Point |
790 ºC at 760 mmHg |
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Flash Point |
431.6 ºC |
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HS CODE |
29322090 |
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PSA |
116.04000 |
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LogP |
5.72890 |
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Pka |
12.46±0.70(Predicted) |
Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin. It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively. Moxidectin (0.2 and 0.3 mg/kg) reduces the worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM. Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.
InChI:InChI=1/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31-/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1
Articles related to Moxidectin:
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Article |
Source |
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Method for preparing moxidectin |
- Paragraph 0046; 0053-0054; 0073-0078, (2020/09/08) |
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A method of preparing mosictin |
- Paragraph 0101-0104, (2017/03/23) |
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