CasNo： 1369852-71-0
The present disclosure provides processe...
The invention relates to a preparation m...
The present invention concerns a process...
5-bromo-3-methyl-thiophene-2-carboxylic acid
![(S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide](/upload/2025/8/43a65963-baa6-47e7-b35b-7b97f0bd7e1a.png)
(S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); XPhos / 1,2-dimethoxyethane / 50 °C / Molecular sieve; Inert atmosphere
2: triethylamine; dmap; di-tert-butyl dicarbonate / toluene / 24 h / 20 °C
3: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.67 h / 20 °C / pH 10
With
dmap; tris-(dibenzylideneacetone)dipalladium(0); di-tert-butyl dicarbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; XPhos;
In
1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;
|
C16H9Cl3F3NO3S
1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride
(S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide
| Conditions | Yield |
|---|---|
|
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.666667h;
pH=10;
|
72% |
1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride
1-(5-bromo-4-methylthiophen-2-yl)ethan-1-one
1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone
C15H8BrCl3F3NOS
